anti-MBP antibody product blog
Tags: Antibody; Myelin Basic Protein; MBP; Monoclonal Antibody; anti-MBP antibody;
The MBP mbp (Catalog #MBS555038) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Myelin Basic Protein, Monoclonal Antibody, Mouse reacts with Human, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Myelin Basic Protein can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF), Western Blot (WB). Researchers should empirically determine the suitability of the MBP mbp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The MBP mbp product has the following accession number(s) (GI #17378805) (NCBI Accession #P02686.3). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Myelin Basic Protein, Monoclonal Antibody, Mouse with the following immunoassay(s):
Testing Data (Image: Shows rat mixed neuron/glial cultures stained with Myelin Basic Protein antibody (red), and also with chicken antibody to neurofilament NF-L (green). Blue is a DNA stain. Note that the MBP antibody stains an oligodendrocyte and some membrane shed from this cell. Other cells in the field include neurons, astrocytes, microglia and fibroblasts, all of which are completely negative for MBP, though the neuronal processes can be seen with the NF-L antibody. Protocol on data-sheet.)
Testing Data (Image: Blots of crude rat spinal cord homogenate blotted with MBP-Mouse Monoclonal Antibody. Protocol on data-sheet.)
Myelin basic protein is reported to account for about 30 of the proteins in myelin found in the central nervous system. It can induce experimental allergic encephalomyelitis (EAE), a T-lymphocyte mediated disease due to delayed-type hypersensitivity; though each animal species appears to respond to a different fragment of the 170 amino acid polypeptide. Four different isoforms have been identified through cDNA cloning. All four of these variants are identical except for the insertion or deletion of two peptide fragments encoded by exons 2 and 5. Myelin basic protein is reported to be expressed in oligodendrocytes, myelin of white matter in the brain and spinal cord and in peripheral nerves, though it is expressed less abundantly in gray matter.
Type Info: Chicken IgY. Immunogen: Mixture of 3 MBP peptides which are the different forms of the protein which are alternate transcription from a single gene. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing MBP are readily searchable from our website. Different antibodies against the same target such as MBP may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.