|The MBP mbp (Catalog #MBS6000233) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The Myelin Basic Protein, aa82-87 (MBP) reacts with Bovine, Human, Mouse, Rabbit, Rat, Sheep and may cross-react with other species as described in the data sheet. MyBioSource\'s Myelin Basic Protein, aa82-87 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).
Suitable for use in Western Blot, ELISA, RIA and Immunohistochemistry. Other applicaitons have not been tested.
Dilution: Immunohistochemistry: Frozen sections. Researchers should empirically determine the suitability of the MBP mbp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The MBP mbp product has the following accession number(s) (GI #1162922) (NCBI Accession #AAC41944.1) (Uniprot Accession #P02686). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Myelin basic protein (MBP) is a single-chain, flexible polypeptide of about 18.5kD existing in its natural environment as an extrinsic and loosely bound component of the cytoplasmic portion of the myelin membrane sandwich. Ultrastructural immunocytochemistry with anti-myelin basic protein has shown that MBP is localized in the compact myelin sheath. MBP has not been demonstrated in rough endoplasmic reticulum, lysosomes or any other cytoplasmic organelles (3). MBP serves as a marker for oligodendrocytes and Schwann cells (3). MBP is also a marker for malignant schwannomas (4) and appears to play a significant role in the etiology of multiple sclerosis (5-7) and experimental autoimmune encephalomyelitis (8).
Immunogen: Bovine myelin basic protein. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing MBP are readily searchable from our website. Different antibodies against the same target such as MBP may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Brain Diseases, Cardiovascular Diseases, Demyelinating Diseases, Disease Models, Animal, Encephalomyelitis, Autoimmune, Experimental, Hypertension, Inflammation, Necrosis, Neoplasms, Nervous System Diseases are some of the diseases may be linked to Myelin Basic Protein, aa82-87 (MBP). Blood, Brain, Heart, Kidney, Lymph, Lymph Node, Muscle, Nerve, Spinal Cord, Spleen tissues are correlated with this protein. The following patways have been known to be associated with this gene.