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anti-MCP-1 antibody product blog

Posted on 2016-02-07 05:30:58 by mybiosource_staff
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Tags: Antibody; MCP-1; Monoclonal Antibody; anti-MCP-1 antibody;
The MCP-1 ccl2 (Catalog #MBS584052) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The MCP-1, Mouse, mAb ECE.2 reacts with Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s MCP-1 can be used in a range of immunoassay formats including, but not limited to, P, Western Blot (WB).
Application Notes: F: Sections (6 um;m) were fixed with 4% PFA, blocked using 0.1% Triton-X and 5% serum for 15min at 37 degree C or o/n 4 degree C and then incubated with 2 ug/ml antibody for 2h at 37 degree C.
Application Use: For immunohistology and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10. Researchers should empirically determine the suitability of the MCP-1 ccl2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The MCP-1 ccl2 product has the following accession number(s) (GI #545465) (NCBI Accession #AAB29926.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Product Description: The monoclonal antibody ECE.2 recognizes mouse monocyte chemoattractant protein 1 (MCP-1). The murine JE gene encodes the monocyte-specific cytokine monocyte chemotactic protein 1 (MCP- 1). MCP-1 is a CC chemokine of 76 amino acids (~11 kDa) and is chemotactic for monocytes and basophils but not neutrophils and eosinophils. MCP-1 is expressed by smooth muscle cells (SMC), macrophages, endothelial cells, keratinocytes and fibroblasts in response to inflammatory stimuli such as interleukin 1beta and tumor necrosis factor alpha. MCP-1 has been implicated in a variety of inflammatory processes, including inflammatory bowel disease, rheumatoid arthritis, asthma, nephritis, and parasitic and viral infections. MCP-1 antigen is not detected in the endothelium or SMC of normal arteries. MCP-1 has also been shown to exhibit biological activities other than chemotaxis. It can induce the proliferation and activation of killer cells known as CHAK (CC-Chemokine-activated killer) MCP-1 signals via the CCR2 receptor, and is critical for aneurysm formation because of its stability to recruit leukocytes. These leukocytes produce extracellular matrix-degrading MMPs, thereby inductin aortic remodelling and dilatation. Interleukin-6 is also involved in this amplification loop accelerating vascular inflammation. MCP-/- mice display significantly delayed wound re-epithelialization, and also delayed wound angiogenesis.

MCP-1 ccl2

Immunogen: Synthetic peptide corresponding to residues 102-130 of mouse MCP-1. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing MCP-1 are readily searchable from our website. Different antibodies against the same target such as MCP-1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.
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