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anti-MGP antibody product blog

Posted on 2018-05-15 22:47:46 by mybiosource_staff
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Tags: Antibody; MGP; Monoclonal Antibody; anti-MGP antibody;
The MGP mgp (Catalog #MBS2541327) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The MGP Monoclonal Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s MGP can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA).
WB: 1:500-1:5000
IHC: 1:20-1:200. Researchers should empirically determine the suitability of the MGP mgp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The MGP mgp product has the following accession number(s) (GI #49574514) (NCBI Accession #NP_000891.2) (Uniprot Accession #P08493). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the MGP Monoclonal Antibody with the following immunoassay(s):
Western Blot (WB) (Western Blot analysis of Transfected HEK-293 cells using MGP Monoclonal Antibody at dilution of 1:1000)
Western Blot (WB) MGP.

Matrix Gla protein (MGP) is is a vitamin K-dependent, extracellular matrix protein. MGP plays a pivotal role in preventing soft tissue calcification and local mineralization of the vascular wall. Vitamin K deficiency leads to inactive uncarboxylated MGP (ucMGP), which accumulates at sites of arterial calcification. However MGP is synthesized in many tissues and is especially enriched in embryonic tissues and in cancer cells. Defects in MGP are the cause of Keutel syndrome (KS), which is an autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia.

Immunogen: Fusion protein of MGP. Buffer: PBS with 0.1% sodium azide, 50% glycerol, PH7.3
Conjugation: Unconjugated. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing MGP are readily searchable from our website. Different antibodies against the same target such as MGP may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Carcinoma, Cardiovascular Diseases, Disease Models, Animal, Heart Diseases, Hypertension, Inflammation, Kidney Diseases, Necrosis, Nervous System Diseases, Vascular Calcification are some of the diseases may be linked to MGP Monoclonal Antibody. Blood, Bone, Brain, Connective Tissue, Heart, Kidney, Liver, Lung, Muscle, Vascular tissues are correlated with this protein. MGP also interacts with the following gene(s): BMP2, DCN, JUN, JUNB, PTH, TGFBI, VEGFA.
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