anti-MICB� antibody product blog
Tags: Antibody; Monoclonal Antibody; MICB�; anti-MICB� antibody;
The MICB� micb (Catalog #MBS2544067) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti Human�MICB� Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s MICB� can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA).ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human MICB. The detection limit for Human MICB is 0.00245 ng/well. Researchers should empirically determine the suitability of the MICB� micb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The MICB� micb product has the following accession number(s) (GI #574584674). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
MHC class I polypeptide-related sequence B, also known as MICB, is a heavily glycosylated protein serving as a ligand for the type I�I receptor NKG2D. MICB shares 85% amino acid identity with MICA, a closely related protein, both of which contain three extracellular immunoglobulin-like domains, but without capacity to bind peptide or interact with beta-2-microglobulin. acting as a stress-induced self-antigen, binding of MICB to the NKG2D receptor activates the cytolytic response of natural killer (NK) cells, CD8+alphabeta T cells, and gammadelta T cells on which the receptor is expressed. MICA/B are minimally expressed on normal cells, but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections. MICA/B recognition thus is involved in tumor surveillance, viral infections, and autoimmune diseases.
Immunogen: Recombinant Human MICB protein
Buffer: This antibody was obtained from a rabbit immunized with purified, recombinant Human MICB (rh MICB; NP_005922.2; Met 1-Gly 298). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing MICB� are readily searchable from our website. Different antibodies against the same target such as MICB� may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Bone Marrow, Brain, Intestine, Kidney, Liver, Lung, Lymph, Thymus, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene. Adenocarcinoma, Breast Neoplasms, Carcinoma, Hepatocellular, Inflammation, Liver Neoplasms, Lung Diseases, Lung Neoplasms, Necrosis, Neoplasm Metastasis, Ovarian Neoplasms are some of the diseases may be linked to Rabbit anti Human�MICB� Monoclonal Antibody.