|The MKK3/6 map2k6 (Catalog #MBS9231158) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-MKK3/6 Antibody reacts with Human, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s MKK3/6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP).
WB: 1:1000. Researchers should empirically determine the suitability of the MKK3/6 map2k6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The MKK3/6 map2k6 product has the following accession number(s) (GI #14589900) (NCBI Accession #NP_002749.2) (Uniprot Accession #P52564). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-MKK3/6 Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of extracts from PC12,C6,Ramos,Jurkat and Hela cell lysates using MKK3/6 mouse mAb (1:1000 diluted).Predicted band size:40KDa.Observed band size:40KDa.)
Immunoprecipitation (IP) (Immunoprecipitation analysis of Hela cell lysates using MKK3/6 mouse mAb.)
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.
Cellular Location: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Binds to microtubules
Tissue Location: Isoform 2 is only expressed in skeletal muscle. Isoform 1 is expressed in skeletal muscle, heart, and in lesser extent in liver or pancreas. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing MKK3/6 are readily searchable from our website. Different antibodies against the same target such as MKK3/6 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Bone, Brain, Eye, Heart, Kidney, Liver, Lung, Muscle, Skin, Thymus tissues are correlated with this protein. MKK3/6 also interacts with the following gene(s): MAP3K4, MAP3K5, MAPK13, MAPK14, RELA, SMAD7, STAT4, TRAF6. The following patways have been known to be associated with this gene. Adenocarcinoma, Brain Diseases, Breast Neoplasms, Cardiovascular Diseases, Inflammation, Liver Diseases, Necrosis, Neoplasms, Neoplasms, Experimental, Nervous System Diseases are some of the diseases may be linked to Anti-MKK3/6 Antibody.