anti-MLKL antibody product blog
Tags: Antibody; Monoclonal Antibody; MLKL; anti-MLKL antibody;
The MLKL mlkl (Catalog #MBS2548823) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Phospho-MLKL (Ser358) Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s MLKL can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry Paraffin (IHC-p).IHC: 1:100-200. Researchers should empirically determine the suitability of the MLKL mlkl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The MLKL mlkl product has the following accession number(s) (GI #215820622) (NCBI Accession #NP_001135969.1) (Uniprot Accession #Q8NB16). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Phospho-MLKL (Ser358) Monoclonal Antibody with the following immunoassay(s):
Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human colon carcinoma tissue with Phospho-MLKL (Ser358) Monoclonal Antibody at dilution of 1:200)
Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human skin tissue with Phospho-MLKL (Ser358) Monoclonal Antibody at dilution of 1:200)
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.MLKL (Mixed Lineage Kinase Domain Like Pseudokinase) is a Protein Coding gene. Among its related pathways are Apoptosis and Autophagy and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.
Immunogen: Synthetic Peptide of Phospho-MLKL (Ser358). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing MLKL are readily searchable from our website. Different antibodies against the same target such as MLKL may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Immune System Diseases, Inflammation, Necrosis, Neoplasms are some of the diseases may be linked to Phospho-MLKL (Ser358) Monoclonal Antibody.