anti-MMP2 antibody product blog
Tags: Antibody; Monoclonal Antibody; MMP2; anti-MMP2 antibody; Matrix Metalloproteinase 2 (MMP2);
The MMP2 mmp2 (Catalog #MBS395066) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Matrix Metalloproteinase 2 (MMP2) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Matrix Metalloproteinase 2 (MMP2) can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the MMP2 mmp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The MMP2 mmp2 product has the following accession number(s) (GI #189217853) (NCBI Accession #NP_001121363.1) (Uniprot Accession #P08253). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Matrix Metalloproteinase 2 (MMP2) with the following immunoassay(s):
Immunohistochemistry (IHC) (A. Immunohistochemical staining of human oesophageal adenocarcinoma tissue using MMP-2 antibody.)
The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-2 (also designated type IV collagenase) cleaves Collagen Types IV, V, VII and X and gelatin type I. Activation of MMP-2 secretion requires the Ras signaling pathway.
Immunogen: Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with a synthetic peptide derived from the C-terminus of the human MMP2 protein and mouse myeloma Ag8563 cells. Positive Control: Oesophageal and gastric tissues. Expression higher cancerous tissue versus normal tissues. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing MMP2 are readily searchable from our website. Different antibodies against the same target such as MMP2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Bone, Brain, Connective Tissue, Heart, Kidney, Liver, Lung, Muscle, Vascular tissues are correlated with this protein. MMP2 also interacts with the following gene(s): COL18A1, IGFBP3, IL1B, MMP14, SRC, TGFB1, THBS2, TIMP1, TIMP2, TIMP3. The following patways have been known to be associated with this gene.