anti-MOB1B antibody product blog
Tags: Antibody; Monoclonal Antibody; MOB1B; anti-MOB1B antibody;
The MOB1B mob1b (Catalog #MBS644459) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The MOB1B (MOB Kinase Activator 1B, Mob1 Homolog 1A, Mob1A, Mob1B, Mps One Binder Kinase Activator-like 1A, MOB4A, MOBKL1A, MGC33910) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s MOB1B can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA).Suitable for use in ELISA. Researchers should empirically determine the suitability of the MOB1B mob1b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The MOB1B mob1b product has the following accession number(s) (GI #348041385) (NCBI Accession #NP_001231696.1) (Uniprot Accession #Q7L9L4). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
TWVQDQLDDE TLFPSKIGVP FPKNFMSVAK TILKRLFRVY AHIYHQHFDP VIQLQEEAHL NTSFKHFIFF VQEFNLIDRR ELAPLQELIE KLTSKDR.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.
Immunogen: Partial recombinant corresponding to aa120-217 from human MOBKL1A (NP_775739) with GST tag. MW of the GST tag alone is 26kD. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing MOB1B are readily searchable from our website. Different antibodies against the same target such as MOB1B may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. MOB1B also interacts with the following gene(s): LATS1, LATS2, MST1, MST4, SAV1, STK3, STK38L.