|The MUC1 muc1 (Catalog #MBS570217) is an Antibody produced from Mouse (Balb/c) and is intended for research purposes only. The product is available for immediate purchase. The Mouse anti MUC-1 (CD227) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s MUC-1 (CD227) can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC), Immunohistochemistry (IHC) (frozen), Immunohistochemistry (IHC) (paraffin).
214D4 is useful for flow cytometry and immunohistochemistry on frozen and paraffin embedded tissue. Optimal antibody dilution should be determined by titRation. Researchers should empirically determine the suitability of the MUC1 muc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The MUC1 muc1 product has the following accession number(s) (GI #324120980) (NCBI Accession #NP_001191225.1) (Uniprot Accession #P15941). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Mucin 1, cell surface associated (MUC-1) or polymorphic epithelial mucin (PEM) is a mucin encoded by the MUC1 gene in Humans. MUC-1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with colon, breast, ovarian, lung and pancreatic cancers.
Source Note: 214D4 is a Mouse monoclonal IgG1 antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with a fusion protein, Human b-gal-episialin/MUC1 repeat domain. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing MUC1 are readily searchable from our website. Different antibodies against the same target such as MUC1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Eye, Intestine, Kidney, Liver, Lung, Ovary, Pancreas, Prostate, Stomach, Uterus tissues are correlated with this protein. Breast Neoplasms, Disease Models, Animal, Inflammation, Liver Diseases, Liver Neoplasms, Lung Neoplasms, Necrosis, Neoplasms, Neoplasms, Experimental, Ovarian Neoplasms are some of the diseases may be linked to Mouse anti MUC-1 (CD227).