anti-MYL3 antibody product blog
Tags: Antibody; Monoclonal Antibody; Myl3; anti-MYL3 antibody;
The MYL3 myl3 (Catalog #MBS475915) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-MYL3 Mouse mAb reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s MYL3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the MYL3 myl3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The MYL3 myl3 product has the following accession number(s) (GI #4557777) (NCBI Accession #NP_000249.1) (Uniprot Accession #P08590). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-MYL3 Mouse mAb with the following immunoassay(s):
Western Blot (WB) (Western blot analysis using MYL3 (1) and MYL2 (2) mouse mAb against rat fetal heart tissues lysate.)
Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded human skeletal muscle (left) and cardiac muscle (right) using MYL3 mouse mAb with DAB staining.)
Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded human Heart tissues using MYL3 mouse mAb.)
Entrez Summary: Myosins are a large superfamily of motor proteins that move along actin filaments, while hydrolyzing ATP. Myosin is the major component of thick muscle filaments, and is a long asymmetric molecule containing a globular head and a long tail. The molecule consists of two heavy chains and four light chains. Activation of smooth and cardiac muscle primarily involves pathways which increase calcium and myosin phosphorylation resulting in contraction. Myosin light chain phosphatase acts to regulate muscle contraction by dephosphorylating activated myosin light chain. MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Human myosin light chain has clinical application as a cardiac marker. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy.
Immunogen: Purified recombinant fragment of MYL3 expressed in E Coli. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing MYL3 are readily searchable from our website. Different antibodies against the same target such as MYL3 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.