anti-NACC1 antibody product blog
Tags: Antibody; Monoclonal Antibody; anti-NACC1 antibody; NACC1;
The NACC1 nacc1 (Catalog #MBS6007655) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The NACC1 reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s NACC1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC).Western Bloting: 1:500-1:2000., Immunohistochemistry: 1:200-1:1000., ELISA: Suggested dilution 1:10000., Optimal dilutions to be determined by the researcher. Researchers should empirically determine the suitability of the NACC1 nacc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The NACC1 nacc1 product has the following accession number(s) (GI #16418383) (NCBI Accession #NP_443108.1) (Uniprot Accession #Q96RE7). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
NAC1 or nuclear accumbens-1 is a nuclear factor that belongs to the POZ/BTB (Pox virus and zinc finger/bric-a-brac tramtrack broad complex) domain family. Also known as BTBD14B, it was originally identified in an unique neuronal forebrain structure responsible for reward motivation and addictive behaviors. NAC1 recruits HDAC3 and HDAC4 to transcriptionally repress gene expression in neuronal cells (3) and specifically co-represses other POZ/BTB proteins in the central nervous system. NAC1 is upregulated in several tumor types, including breast, renal cell, and hepatocellular carcinoma, as well as high grade ovarian serous carcinoma, where it has long been suspected as a chemoresistance gene. The chemoresistance mechanism reportedly occurs through NAC1 negative regulation of the GADD45 pathway. NAC1 has also been described as part of the extended transcriptional network in pluripotent cells that involves Oct-4, Sox2, Nanog, Sall1, KLF4 and Sall4. Tissue specificity: Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer.
Immunogen: Purified recombinant fragment of human NACC1 expressed in E. coli. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing NACC1 are readily searchable from our website. Different antibodies against the same target such as NACC1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.