|The NBN nbn (Catalog #MBS606516) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Nibrin, p95, phosphorylated (Ser343) (Nijmegen Breakage Syndrome, NBS1) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Nibrin, p95 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP).
Suitable for use in Western Blotting, Immunoprecipitation. Researchers should empirically determine the suitability of the NBN nbn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The NBN nbn product has the following accession number(s) (GI #33356172) (NCBI Accession #NP_002476.2) (Uniprot Accession #O60934). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
The Nijmegen breakage syndrome (NBS) is characterized by defects in cell cycle checkpoints, growth retardation, an increased propensity for cancer and sensitivity to ionizing radiation (1). Repair of DNA double-strand breaks by radiation is dependent on a multifunctional complex containing Rad50, Mre11 and the NBS1 gene product p95/NBS1 (also called p95 or nibrin) (2). p95/NBS1 is a protein with a forkhead-associated domain and a carboxy-terminal repeat frequently found in cell cycle regulatory and DNA repair proteins (1,3). The overlap between clinical and cellular phenotypes in ataxia telangiectasia (AT) and NBS suggests that AT-mutated (ATM) and p95/NBS1 may function in the same biochemical pathway. Recent research has shown that ATM interacts with and phosphorylates p95/NBS1 on Ser343 after IR (4-7).
Immunogen: KLH-conjugated, synthetic phosphopeptide corresponding to amino acids 337-350 (TPGPSLpSQGVSVDE) of human Nibrin/nbs1. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing NBN are readily searchable from our website. Different antibodies against the same target such as NBN may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Bladder, Blood, Bone, Brain, Eye, Kidney, Liver, Lung, Prostate, Skin tissues are correlated with this protein. The following patways have been known to be associated with this gene. NBN also interacts with the following gene(s): ATM, BRCA1, H2AFX, MDC1, MDM2, MRE11A, NFBD1, RAD50, SIRT1. Anemia, Breast Neoplasms, Carcinoma, Cardiovascular Diseases, Colorectal Neoplasms, Leukemia, Neoplasms, Nervous System Diseases, Nijmegen Breakage Syndrome, Ovarian Neoplasms are some of the diseases may be linked to Nibrin, p95, phosphorylated (Ser343) (Nijmegen Breakage Syndrome, NBS1).