anti-NEFL antibody product blog
Tags: Antibody; Monoclonal Antibody; NEFL; anti-NEFL antibody; Neurofilament NF-L;
The NEFL nefl (Catalog #MBS415293) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s Neurofilament NF-L can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF), Western Blot (WB).For immunofluorescence, use MCA-7D1 diluted 1:50 to 1:250. For western blots try MCA-7D1 diluted 1:2500 to 1:5000. Researchers should empirically determine the suitability of the NEFL nefl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The NEFL nefl product has the following accession number(s) (GI #105990539) (NCBI Accession #NP_006149.2) (Uniprot Accession #P07196). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Neurofilament NF-L Antibody with the following immunoassay(s):
Western Blot (WB)
Immunogen: Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-L is the neurofilament light or low molecular weight polypeptide and runs on SDS-PAGE gels at about 68kDa. Antibodies to NF-L are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. NF-L antibody can also be useful in the neurofilament accumulations seen in many neurological diseases, such as Lou Gehrig\'s disease and Alzheimer\'s disease. Mutations in the protein coding region of the human NF-L gene cause some forms of Charcot-Marie-Tooth disease (1). Storage Buffer: PBS, pH 7.4 with 0.02% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing NEFL are readily searchable from our website. Different antibodies against the same target such as NEFL may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Bone Marrow, Brain, Eye, Ganglia, Kidney, Liver, Lung, Nerve, Prostate, Spinal Cord tissues are correlated with this protein. NEFL also interacts with the following gene(s): GAN, MTMR2, NEFH, TSC1. The following patways have been known to be associated with this gene. Ataxia, Brain Diseases, Breast Neoplasms, Charcot-Marie-Tooth disease, Type 1F, Neoplasms, Nervous System Diseases, Nervous System Malformations, Pain, Peripheral Nervous System Diseases, Polyneuropathies are some of the diseases may be linked to Neurofilament NF-L Antibody.