anti-Neurofilament alpha-internexin/NF66 antibody product blog
Tags: Antibody; Monoclonal Antibody; Neurofilament alpha-internexin/NF66; anti-Neurofilament alpha-internexin/NF66 antibody;
The INA ina (Catalog #MBS555019) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Mouse Monoclonal Anti-alpha-Internexin [1D2] reacts with Human, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s alpha-Internexin [1D2] can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB). Researchers should empirically determine the suitability of the INA ina for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The INA ina product has the following accession number(s) (GI #14249342) (NCBI Accession #NP_116116.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Mouse Monoclonal Anti-alpha-Internexin [1D2] with the following immunoassay(s):
Testing Data (Image: Mixed cultures of rat CNS cells stained with alpha-Internexin (red) and chicken antibody to Microtubule associated protein 2 (MAP2- green). The a-internexin is localized primarily in neuronal axons in these cultures, while the perikarya and dendrites of neurons stain strongly for MAP2.)
Alpha-Internexin is a ~66 kDa Class IV intermediate filament subunit expressed very early in neuronal development. It is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H, having similar protein sequence motifs and a similar intron organization. Many classes of mature neurons contain alpha-internexin in addition to NF-L, NF-M and NF-H. In some mature neurons alpha-internexin is the only neurofilament subunit expressed. Antibodies to internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. In addition the very early developmental expression of alpha-internexin means its presence is an early and convenient feature of neuronal progenitors cells and other cell committed to the neuronal lineage. The use of antibodies to this protein in the study of brain tumors has not been examined to date, but is likely to be of interest.
Type Info: Mouse IgG. Immunogen: Purified recombinant rat alpha-internexin expressed in and purified from E Coli. Specifically recognizes the C-terminal non-helical extension of a-internexin. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing INA are readily searchable from our website. Different antibodies against the same target such as INA may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.