|The NME1 n/a (Catalog #MBS283579) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse anti-human Non Metastatic Cells 1, Protein NM23A Expressed In (NME1) monoclonal antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Non Metastatic Cells 1 can be used in a range of immunoassay formats including, but not limited to, Western Blot Analysis (WB), Immunohistochemistry (IHC), ELISA (EIA). Researchers should empirically determine the suitability of the NME1 n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The NME1 n/a product has the following accession number(s) (GI #213510934) (NCBI Accession #NP_001133149.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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NME1 was identified because of its reduced mRNA transcript levels in highly metastatic cells. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein consisting of sequence sharing identity with each individual gene product.
Human NM23 protein has sequence homology over the entire translated region with a developmentally related protein in Drosophila encoded by the \'abnormal wing discs\' (awd) gene. Mutations in awd cause abnormal tissue morphology and necrosis and widespread aberrant differentiation in Drosophila, analogous to the changes in malignant progression.
Storage Buffer: PBS, pH: 7.20, 1% BSA, 0.02% Sodium azide.
Conjugate: Non-conjugated; FITC--conjugated
Immunogen: Recombinant protein, corresponding to the full-length of human NME1. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing NME1 are readily searchable from our website. Different antibodies against the same target such as NME1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.