anti-NOTCH1 antibody product blog
Tags: Antibody; Monoclonal Antibody; NOTCH1; anti-NOTCH1 antibody;
The NOTCH1 notch1 (Catalog #MBS190928) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s Notch1 can be used in a range of immunoassay formats including, but not limited to, Immunoblot (IB).Immunoblotting: Use at 1ug/ml. Bands of >270kDa, ~120kDa, and smaller fragments (due to proteolysis) are detected. Researchers should empirically determine the suitability of the NOTCH1 notch1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The NOTCH1 notch1 product has the following accession number(s) (GI #48146559) (NCBI Accession #CAG33502.1) (Uniprot Accession #Q6IAD4). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Members of the Notch trans-membrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. The Notch signaling network is an intercellular signaling pathway that regulates interactions between physically adjacent cells. The Notch1 protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. It functions as a receptor for membrane bound ligands, and may play multiple roles during development. There is evidence that activated Notch 1 and Notch 3 promot differentiation of progenitor cells into astroglia. Notch 1, activated before birth, induces radial glia differentiation,but postnatally induces the differentiation into astrocytes.
Antigen: Fusion protein corresponding to aa 20-216 (extracellular N-terminus, EGF-like domains 1-5) of mouse Notch1 (accession no. Q01705). Positive Control: Rat brain lysate
Dilution Instructions: Dilute in PBS or medium which is identical to that used in the assay system. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing NOTCH1 are readily searchable from our website. Different antibodies against the same target such as NOTCH1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Blood, Bone, Bone Marrow, Brain, Embryonic Tissue, Heart, Liver, Lung, Muscle, Vascular tissues are correlated with this protein.