Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
Fax 1.858.633.0166    Email 
menu1 Home Products Ordering Company Help menu7
   MyBioSource  rightarrow Monoclonal Antibody Blog  rightarrow anti-Notch1 antibody  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Blogs moreseparator
 • anti-CD11c antibody blog
 • anti-CDA antibody blog
 • anti-Tetrahydrocannabinol, D9 antibody blog
 • anti-TNF-alpha antibody blog
 • anti-KIT  antibody blog
 • anti-Mitochondria antibody blog
 • anti-PP2A C-terminal antibody blog
 • anti-NPHN antibody blog
 • anti-Pcdhgb2 antibody blog
 • anti-Grm5 antibody blog
 • anti-IMPA1 antibody blog
 • anti-AFP antibody blog
 • anti-Multi Epitope Cocktail to Nucleolar Organizer Region antibody blog
 • anti-HSP60 antibody blog
 • anti-SerpinA3/AACT antibody blog
 • anti-HK2 antibody blog
 • anti-HHEX antibody blog
 • anti-Calpain 1 antibody blog
 • anti-ARPC5 antibody blog
 • anti-KDELR antibody blog
Blog Categories separator
 • Assay Kit Blogs
 • Biochemical Blogs
 • cDNA Clone Blogs
 • Monoclonal Antibody Blogs
 • Polyclonal Antibody Blogs
 • Rec/Purified Protein Blogs
 • Popular Product Blogs
Our Best Sellers moreseparator
 • Benzoylecgonine Protein
 • Methionine Synthase (MTR) ELISA Kit
 • Glutathione S-Transferase pi 1 (GSTP1) Recombinant Protein
 • pituitary growth hormone 22K (GH1) Recombinant Protein
 • EGFL8 cDNA Clone
 • tripartite motif-containing 54 (TRIM54) Antibody
 • Hepatitis C Virus Nucleocapsid (HCV) Recombinant Protein
 • ENPP1-PC1 Antibody
 • Carboxy-terminal telopepide type I collagen (ICTP) ELISA Kit
 • Soluble cluster of differentiation 86 (SCD86) ELISA Kit
 • Von Willebrand Factor Cleaving Protease (VWF-CP) ELISA Kit
 • Keratin 7 (KRT7) Antibody
 • AADACL2 Antibody
 • choroideremia (Rab escort protein 1) (CHM) ELISA Kit
 downarrow more ...

anti-Notch1 antibody product blog

Posted on 2015-08-21 10:04:29 by mybiosource_staff
Share it on ...     
Tags: Antibody; Monoclonal Antibody; NOTCH1; anti-NOTCH1 antibody;
The Notch1 notch1 (Catalog #MBS802191) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Notch1 Antibody: ATTO 565 reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Notch1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC).
1:1000 (WB). Researchers should empirically determine the suitability of the Notch1 notch1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The Notch1 notch1 product has the following accession number(s) (GI #224967065) (NCBI Accession #NP_032740.3) (Uniprot Accession #Q01705). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Background Info: Detects >270kDa, ~120kDa and small fragments due to proteolysis. Does not cross-react with Notch2 or Notch3.

Scientific Background: Notch is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane.

Notch1 notch1

Conjugate: ATTO 565. Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Notch1 are readily searchable from our website. Different antibodies against the same target such as Notch1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Adenocarcinoma, Breast Neoplasms, Cell Transformation, Neoplastic, Congenital Abnormalities, Inflammation, Liver Diseases, Lung Neoplasms, Lymphoma, Nervous System Diseases, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma are some of the diseases may be linked to Notch1 Antibody: ATTO 565. Blood, Bone, Bone Marrow, Brain, Embryonic Tissue, Heart, Liver, Muscle, Skin, Thymus tissues are correlated with this protein. The following patways have been known to be associated with this gene.
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions