anti-NPDC-1 antibody product blog
Tags: Antibody; Monoclonal Antibody; NPDC-1; anti-NPDC-1 antibody;
The NPDC-1 n/a (Catalog #MBS395295) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The NPDC-1 reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s NPDC-1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the NPDC-1 n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The NPDC-1 n/a product has the following accession number(s) (GI #74716344) (NCBI Accession #Q8WXX4) (Uniprot Accession #Q8WXX4). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the NPDC-1 with the following immunoassay(s):
Western Blot/Blotting (Lane 1. Western blot using anti-NPDC-1 on 10 ug lysate transfected with NPDC-1 protein at a dilution of 1ug/ml, detected with Supersignal West Pico Substrate, 15 second exposure. Lane 2 probed with anti-Rem and anti-alpha SNAP antibodies.)
The discovery of NPDC-1 (neuronal proliferation, differentiation and control protein 1) was the result of a study of genes that were preferentially expressed in immortalized neural precursor cell lines at the onset of contact inhibition of proliferation and subsequent differentiation. It was further found that transfection of transformed cells with NPDC-1 led to increased doubling times and suppression of many characteristics of transformation. NPDC-1 is differentially expressed in brain and lung and has been shown to interact directly with the transcription factor E2F-1 as well as D-type cyclins and cdk2. NPDC-1 has been identified as a modulator of transcriptiona levents mediated by retinoic acid and the protein level and activity of NPDC-1 have been shown to be regulated by phosphorylation mediated proteasomal degradation.
Immunogen: Hybridoma produced by the fusion of splenocytes from mice immunized with a synthetic peptide derived from human NPDC-1 protein and mouse myeloma cells. Positive Control: Brain tissue lysate (mouse and rat tested, human not yet tested). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing NPDC-1 are readily searchable from our website. Different antibodies against the same target such as NPDC-1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.