|The NR3C2 nr3c2 (Catalog #MBS604255) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mineralocorticoid Receptor (MR) reacts with Chicken, Human, Rabbit, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Mineralocorticoid Receptor can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC).
Suitable for use in Western Blot, Immunocytochemistry, Immunohistochemistry and Functional Assays. Not suitable for use in Immunoprecipitation.
Dilution: Western Blot: 1:1000 using ECL.
Immunohistochemistry (Paraffin): 1:100. Staining is blocked by pre-incubating the sample with aldosterone.
Functional Assays: Blocks the binding of aldosterone to the MR. Researchers should empirically determine the suitability of the NR3C2 nr3c2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The NR3C2 nr3c2 product has the following accession number(s) (GI #307166) (Uniprot Accession #P08235). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Steroid receptors are ligand dependent, intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Mineralocorticoids are a family of steroids, secreted by the adrenal cortex, necessary for the regulation of a number of metabolic processes including electrolyte regulation. These compounds exert their effect through their interaction with the mineralocorticoid receptor and that complex\'s subsequent association with DNA. Given the function of mineralocorticoids, it is not surprising to find that the kidney is a primary target organ for mineralocorticoids and that this organ has been shown to contain MR.
Immunogen: Aldosterone. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing NR3C2 are readily searchable from our website. Different antibodies against the same target such as NR3C2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Brain, Embryonic Tissue, Intestine, Kidney, Liver, Lung, Muscle, Placenta, Thyroid, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene. NR3C2 also interacts with the following gene(s): FKBP4, NR3C1, PIAS1, PIAS3. Cardiovascular Diseases, Fibrosis, Genetic Diseases, Inborn, Heart Failure, Hypertension, Hypertrophy, Inflammation, Kidney Diseases, Neoplasms, Vascular Diseases are some of the diseases may be linked to Mineralocorticoid Receptor (MR).