anti-OTOP2 antibody product blog
Tags: Antibody; Monoclonal Antibody; OTOP2; anti-OTOP2 antibody;
The OTOP2 n/a (Catalog #MBS6010326) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The OTOP2 (Otopetrin 2, Otopetrin-2) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s OTOP2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).Suitable for use in ELISA and Western Blot. Researchers should empirically determine the suitability of the OTOP2 n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below:
ESLHRGPPGA EPHSTHPKEP CQDLTFTNLD ALHTLSACPP NPGLVSPSPS DQREAVAIVS TPRSQWRRQC L.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the OTOP2 (Otopetrin 2, Otopetrin-2) with the following immunoassay(s):
Western Blot (WB) (Western Blot detection against Immunogen (33.92kD).)
Western Blot (WB) (OTOP2 monoclonal antibody. Western Blot analysis of OTOP2 expression in MCF-7.)
Testing Data (Detection limit for recombinant GST tagged OTOP2 is 0.1ng/ml as a capture antibody.)
Otopetrins are multi-transmembrane domain proteins that share conserved gene and protein structure and are possibly involved in the formation of otoconia and otoliths. Located in the utricle and saccule of the inner ear, otoconia are complex calcium carbonate biominerals that are required for the normal sensation of gravity and linear acceleration. Vertigo and loss of balance may be attributed to degeneration of displacement of otoconia. The otopetrin family consists of three proteins, OTOP1, OTOP2 and OTOP3. These proteins have 12 putative transmembrane domains that are clustered into three otopetrin domains (OD-I, II and III). OTOP1 was the first described member of the Otopetrin family. Mutations of OTOP1 leads to absence of otoconia or otoliths, though inner ear development is normal. OTOP2 and OTOP3 share significant structural similarity with OTOP1 and may also play a role in the formation of mineralized structures.
Immunogen: Partial recombinant corresponding to aa423-494 from human OTOP2 (NP_835454) with GST tag. MW of the GST tag alone is 26kD. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing OTOP2 are readily searchable from our website. Different antibodies against the same target such as OTOP2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.