anti-p53 antibody product blog
Tags: Antibody; anti-p53 antibody; p53; Monoclonal Antibody; p53 (a.a. 20-25);
The p53 tp53 (Catalog #MBS395159) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The p53 (a.a. 20-25) reacts with Human only and may cross-react with other species as described in the data sheet. MyBioSource\'s p53 (a.a. 20-25) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC) Paraffin. Researchers should empirically determine the suitability of the p53 tp53 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The p53 tp53 product has the following accession number(s) (GI #120407068) (NCBI Accession #NP_000537.3) (Uniprot Accession #P04637). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
p53 is a 53 kDa transcription factor that can inhibit cell cycle progression or induce apoptosis in response to stress or DNA damage. Disruption of the p53 signalling pathway through various mechanisms is the most common alteration in human cancer occuring in over half of all tumors. The p53 protein is short lived and expressed at low levels in normal cells but accumulates and/or is activated in cells that have undergone genotoxic damage or oncogene activation. Many tumor derived and transformed cell lines express elevated levels of mutant p53 protein. Other genes also implicated in the downstream effects as a result of p53 activation are: p21WAF1, GADD45, 14-3-3, bax, Fas/APO1, KILLER/ DR5, Tsp1, IGF-BP3 and others.
Immunogen: Hybridoma produced by the fusion of splenocytes from immunized with full length wild-type human p53 protein and mouse myeloma cells. Positive Control: MCF-7 cell line. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing p53 are readily searchable from our website. Different antibodies against the same target such as p53 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Blood, Brain, Kidney, Liver, Lung, Lymph, Muscle, Prostate, Skin, Vascular tissues are correlated with this protein. Breast Neoplasms, Carcinoma, Carcinoma, Small Cell, Carcinoma, Squamous Cell, Cell Transformation, Neoplastic, Colorectal Neoplasms, Glioma, Neoplasm Metastasis, Sarcoma, Urogenital Neoplasms are some of the diseases may be linked to p53 (a.a. 20-25).