|The p73, alpha, beta, gamma, delta n/a (Catalog #MBS6005811) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The p73, alpha, beta, gamma, delta (Tumor Protein p73, p53-like Transcription Factor, p53-related Protein, TP73) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s p73, alpha, beta, gamma, delta can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF).
Suitable for use in ChIP, Immunofluorescence, Western Blot, Immunoprecipitation and Immunocytochemistry.
Dilution: Western Blot: 1-3ug/ml. Researchers should empirically determine the suitability of the p73, alpha, beta, gamma, delta n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
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p73 was identified as a long-lost cousin of tumor suppressor protein, p53. p73 has high homology with p53 as well as with p63, a gene implicated in the maintenance of epithelial stem cells. Significant homology between p53, p63, and p73 (approximately 63% aa identity in the DNA-binding domain suggest that they may have overlapping functions in the regulation of gene expression. The targeted disruption of p73 gene leads to defects hippocampal dysgenesis, hydrocephalus, chronic inflammation and infections. Recently, spilicing variant mRNAs of p73 has been identified in MCF-7, a breast carcinoma cell line. These mRNAs code for variant p73 proteins bearing distinct carboxy-terminal structures suggesting that the carboxy-terminal region of p73 may be important for the functions of this protein. Tumor BioMarker/ Vella et al (2003) found p73 to be upregulated in a significant fraction of anaplastic thyroid cancers, whereas it was not detectable in normal thyroid epithelial cells nor in papillary or follicular thyroid cancer.
Immunogen: Full-length human p73. Positive Control: p73 transfected cells. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing p73, alpha, beta, gamma, delta are readily searchable from our website. Different antibodies against the same target such as p73, alpha, beta, gamma, delta may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.