anti-PAX5 antibody product blog
Tags: Antibody; Monoclonal Antibody; anti-PAX5 antibody; PAX5;
The PAX5 pax5 (Catalog #MBS476332) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-PAX5 Mouse mAb reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s PAX5 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the PAX5 pax5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The PAX5 pax5 product has the following accession number(s) (GI #525507362) (NCBI Accession #NP_001267481.1) (Uniprot Accession #Q02548). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-PAX5 Mouse mAb with the following immunoassay(s):
Western Blot (WB) (Western blot analysis using PAX5 mAb against human PAX5 recombinant protein. (Expected MW is 41.2 kDa))
Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded brain tumors tissues using PAX5 mouse mAb with DAB staining.)
Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded endometrial cancer tissues using PAX5 mouse mAb with DAB staining.)
Entrez Summary: This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t (9; 14) (p13; q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.
Immunogen: Purified recombinant fragment of human PAX5 (AA: 235-382) expressed in E Coli. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PAX5 are readily searchable from our website. Different antibodies against the same target such as PAX5 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.