anti-PAXIP1 antibody product blog
Tags: Antibody; Monoclonal Antibody; PAXIP1; anti-PAXIP1 antibody;
The PAXIP1 paxip1 (Catalog #MBS645736) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The PAXIP1 (PAX-interacting Protein 1, PAX Transactivation Activation Domain-interacting Protein, PAXIP1L, PTIP, CAGF28, CAGF29, FLJ41049, TNRC2) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s PAXIP1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).Suitable for use in ELISA and Western Blot. Researchers should empirically determine the suitability of the PAXIP1 paxip1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PAXIP1 paxip1 product has the following accession number(s) (GI #93141033) (NCBI Accession #NP_031375.3) (Uniprot Accession #Q6ZW49). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
HLIASKVTRT VKFLTAISVV KHIVTPEWLE ECFRCQKFID EQNYILRDAE AEVLFSFSLE ESLKRAHVSP LFKAKYFYIT PGICPSLSTM KAIVECAGGK VLSKQPSF*.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the PAXIP1 (PAX-interacting Protein 1, PAX Transactivation Activation Domain-interacting Protein, PAXIP1L, PTIP, CAGF28, CAGF29, FLJ41049, TNRC2) with the following immunoassay(s):
Western Blot (WB) (Western Blot detection against Immunogen (37.99kD).)
Testing Data (Detection limit for recombinant GST tagged PAXIP1 is 0.3ng/ml as a capture antibody.)
Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires RNF8 and UBE2N. Recruits TP53BP1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to require the association with TP53BP1 phosphorylated by ATM at \'Ser-25\'. Together with TP53BP1 regulates ATM association. Recruits PAGR1 to sites of DNA damage and the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage; the function is probbaly independent of MLL-containing histone methyltransferase (HMT) complexes. Promotes ubiquitination of PCNA following UV irradiation and may regulate recruitment of polymerase eta and RAD51 to chromatin after DNA damage. Proposed to be involved in transcriptional regulation by linking MLL-containing histone methyltransferase (HMT) complexes to gene promoters by interacting with promoter-bound transcription factors such as PAX2. Associates with gene promoters that are known to be regulated by MLL2. During immunoglobulin class switching in activated B-cells is involved in trimethylation of histone H3 at \'Lys-4\' and in transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus; this function appears to involve the recruitment of MLL-containing HMT complexes.