anti-PDE4A antibody product blog
Tags: Antibody; Monoclonal Antibody; PDE4A; anti-PDE4A antibody;
The PDE4A pde4a (Catalog #MBS833828) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s PDE4A can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC).FC: 1:100, IF: 1:100, IHC: 1:50. Researchers should empirically determine the suitability of the PDE4A pde4a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PDE4A pde4a product has the following accession number(s) (GI #5453862) (NCBI Accession #NP_006193) (Uniprot Accession #P27815). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the PDE4A antibody with the following immunoassay(s):
Western Blot (WB) (Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant PDE4A protein (Right) or empty vector (Left) detected with PDE4A antibody)
Immunohistochemistry (IHC) (Immunohistochemical analysis of PDE4A protein in paraffin embedded Human prostate tissue using PDE4A antibody)
Immunofluorescence (IF) (Immunofluorescent staining of COS7 cells transiently transfected with recombinant PDE4A protein using PDE4A antibody)
Mouse monoclonal PDE4A antibody.
Biological Significance: Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. Cyclic nucleotide phosphodiesterases (PDEs)regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. PDE4A is a class IV cAMP-specific PDE. Cross-Reactivity: Human
Immunogen: PDE4A antibody was raised in mouse using a full length recombinant protein of human PDE4A (NP_006193) produced in HEK293T cells, as the immunogen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PDE4A are readily searchable from our website. Different antibodies against the same target such as PDE4A may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Bone, Brain, Embryonic Tissue, Kidney, Liver, Lung, Muscle, Spleen, Testis tissues are correlated with this protein. The following patways have been known to be associated with this gene. Cardiovascular Diseases, Cognition Disorders, Fibrosis, Heart Diseases, Hypertension, Inflammation, Memory Disorders, Mental Disorders, Necrosis, Neurobehavioral Manifestations are some of the diseases may be linked to PDE4A antibody.