Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource  rightarrow Monoclonal Antibody Blog  rightarrow anti-PDL-1 antibody  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Blogs moreseparator
separator
 • anti-COL18A1 antibody blog
 • anti-ATPase, p97 antibody blog
 • anti-HSP27 antibody blog
 • anti-14-3-3 antibody blog
 • anti-CST3 antibody blog
 • anti-SRSF9 antibody blog
 • anti-cAMP antibody blog
 • anti-CRP antibody blog
 • anti-FMNL1 antibody blog
 • anti-Hspa5 antibody blog
 • anti-HMOX1 antibody blog
 • anti-Vibrio Cholera Toxin B antibody blog
 • anti-CHRNA7 antibody blog
 • anti-ABCG1 antibody blog
 • anti-Omi, HtrA2 antibody blog
 • anti-MYBBP1A antibody blog
 • anti-Myc antibody blog
 • anti-HP antibody blog
 • anti-HSP90 antibody blog
 • anti-JEV PreM antibody blog
separator
Blog Categories separator
separator
 • Assay Kit Blogs
 • Biochemical Blogs
 • cDNA Clone Blogs
 • Monoclonal Antibody Blogs
 • Polyclonal Antibody Blogs
 • Rec/Purified Protein Blogs
 • Popular Product Blogs
separator
Our Best Sellers moreseparator
separator
 • Histone H4 (HIST1H4A) ELISA Kit
 • transient receptor potential cation channel, subfamily V, me... ELISA Kit
 • Caspase-3 ELISA Kit
 • Epstein Barr IgG ELISA Kit
 • Galectin 12 (GAL12) Recombinant Protein
 • Ebola GP I Antibody
 • Foot-And-Mouth Disease Virus Antibody (Anti-FMDV) ELISA Kit
 • Immunoglobulin G (IgG) ELISA Kit
 • Transferrin (TF) Native Protein
 • 14-3-3 eta-YWHAH Antibody
 • AIRE Peptide
 • ACTR1B - PC3 Antibody
 • Alanine Transaminase (CLF_105569) Antibody
 • HSV-2 IgM ELISA Kit
 downarrow more ...
separator

anti-PDL-1 antibody product blog

separator
Posted on 2017-04-21 09:28:26 by mybiosource_staff
Share it on ...     
separator
separator
Tags: Antibody; Monoclonal Antibody; PDL-1; anti-PDL-1 antibody;
separator
The PDL-1 n/a (Catalog #MBS592439) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse monoclonal antibody to human PDL-1 reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s PDL-1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB).
ELISA: Indirect ELISA: The antibody reacts with recombinant PDL-1 in indirect ELISA.
Western Blot: Anti-PDL-1 clone 12D9 detected 40ng recombinant PDL-1 on Western Blot. The blot was stained with HRP substrate 4-Chloro-1-Naphthol. Researchers should empirically determine the suitability of the PDL-1 n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Mouse monoclonal antibody to human PDL-1 with the following immunoassay(s):
Western Blot (WB)
Western Blot (WB) PDL-1.

Programmed Death Ligand-1 (PDL-1), a 40KD transmembrane protein, is a ligand of immune checkpoint protein Programmed Death-1 (PD-1). During T-cell receptor signalling, the binding of PDL-1 to PD-1 transmits an inhibitory signal to activated T-cells to decrease their proliferation. PDL-1 is also believed to play a role in the generation and regulation of Treg cells, and in the enhancement of Treg cell function. PDL-1/PD-1 pathway is important to immune suppression, such as self-tolerance, suppression of immune-rejection during pregnancy and allograft, and immune evasion by cancers. Upregulation of PD-L1 has been found to be associated with many cancer types. For example, increased PDL-1 expression has been shown to be related to tumor aggressiveness and higher mortality in patients with renal cell carcinoma, and related to significantly poorer prognosis and lower intraepithelial CD8+ T-lymphocyte count in patience with ovarian cancer. Antibodies that block the PDL-1 /PD-1 pathway have been extensively studied in clinical trials, and some have been approved as immunotherapy for cancer.  .

Target Protein: Human programmed death ligand-1 (PDL-1), also known as B7H1 or CD274.
Immunogen: Human cell expressed recombinant PDL-1 (Phe19-Arg238) with poly-histidine tag at C-terminus. Fusion Myeloma: SP2/0
Reconstitution: Double distilled water is recommended to reconstitute the antibody to 1mg/mL. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PDL-1 are readily searchable from our website. Different antibodies against the same target such as PDL-1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions