|The PGR pgr (Catalog #MBS632365) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Progesterone Receptor, pHOSPHORYLATED (Ser294) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Progesterone Receptor, pHOSPHORYLATED can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC).
Suitable for use in Western Blot and Immunohistochemistry (frozen).
Dilution: Immunohistochemistry: 1:1000
Western Blot: 1:1000
Optimal dilution determined by the researcher. Researchers should empirically determine the suitability of the PGR pgr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PGR pgr product has the following accession number(s) (GI #189935) (Uniprot Accession #P06401). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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The progesterone receptor is a member of the Steroid Hormone Receptor Superfamily, which is expressed in a range of tissues, including ovary, endometrium, uterus and placenta. Recent research suggests that progesterone plays a key role in the regulation and differentiation of mammary glands, and may be implicated in certain types of breast cancer. Progesterone receptor (PR) exists in two distinct isoforms in human cells, PR-An and PR-B. PR-An is identical to PR-B except for a 165 amino acid deletion at the N-terminus. Recognizes both PR-An and PR-B, when phosphorylated at serine 294.
Immunogen: Synthetic phosphopeptide corresponding to an amino acid sequence within human progesterone receptor which includes phosphorylated Ser 294. Hybridoma: Spleen cells from immunized Balb/c mice were fused with cells of the mouse SP2/0 myeloma cell line. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PGR are readily searchable from our website. Different antibodies against the same target such as PGR may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Brain, Cervix, Lung, Mammary Gland, Muscle, Ovary, Prostate, Stomach, Uterus, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene. Adenocarcinoma, Breast Neoplasms, Carcinoma, Female Urogenital Diseases, Genital Neoplasms, Female, Neoplasm Recurrence, Local, Neoplasms, Neoplasms, Experimental, Neoplasms, Hormone-Dependent, Uterine Neoplasms are some of the diseases may be linked to Progesterone Receptor, pHOSPHORYLATED (Ser294). PGR also interacts with the following gene(s): ESR1, KLF9, NCOA1, NCOA3, RELA, SP1, SRC.