|The PLEK plek (Catalog #MBS2541363) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The PLEK Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s PLEK can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA).
IHC: 1:50-1:500. Researchers should empirically determine the suitability of the PLEK plek for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PLEK plek product has the following accession number(s) (GI #156616273) (NCBI Accession #NP_002655.2) (Uniprot Accession #P08567). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the PLEK Monoclonal Antibody with the following immunoassay(s):
Western Blot (WB) (Western Blot analysis of HL-60 cells using PLEK Monoclonal Antibody at dilution of 1:5000)
PLEK (pleckstrin; also known as p47) was originally identified as the major PKC substrate in platelets and later is found to be expressed in all cells of the hemopoietic system. Through two pleckstrin homology (PH) domains at its N and C termini, PLEK may interact with various protein and/or lipid ligands and serve as an intracellular adaptor/targeting protein. Predominantly cytosolic in unstimulated cells, PLEK would undergo transient redistribution to phagosomal membrane in response to stimuli. PLEK has been found to be hyperphosphorylated in diabetic mononuclear phagocytes and promote proinflammatory cytokine secretion in diabetes. (10477609, 17579087).
Immunogen: Fusion protein of PLEK. Buffer: PBS with 0.02% sodium azide, 50% glycerol, PH7.3
Conjugation: Unconjugated. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PLEK are readily searchable from our website. Different antibodies against the same target such as PLEK may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Bone, Brain, Eye, Heart, Lung, Mammary Gland, Ovary, Spleen, Vascular tissues are correlated with this protein. Edema, Hypertension, Inflammation, Skin Diseases are some of the diseases may be linked to PLEK Monoclonal Antibody. The following patways have been known to be associated with this gene.