|The POP7 pop7 (Catalog #MBS649830) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s Ribonuclease P Protein Subunit p20 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: Under less stringent washing conditions, a weaker band of ~60kD is also detected. Researchers should empirically determine the suitability of the POP7 pop7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The POP7 pop7 product has the following accession number(s) (GI #153791431) (NCBI Accession #NP_005828.2) (Uniprot Accession #O75817). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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The nuclei of eukaryotic cells contain several classes of small RNA-protein complexes. SnRNPs (small nuclear ribonucleoproteins) are involved in splicing of pre-mRNAs (the excision of introns) in the nucleoplasm. RPP20 is part of such a complex. SnoRNPs (small nucleolar ribonucleoproteins) are involved in the maturation of pre-ribosomal RNA in the nucleoli. Pre-rRNA processing and modification require both the snoRNA and the protein constituents (such as Rpp20) of these complexes. Generally, snoRNPs contain a number of common proteins, which are shared with other snoRNPs of the same family, next to several particle- specific proteins. On average, snoRNPs contain about 6-10 protein subunits.
Immunogen: Recombinant GST-hRPP20 (Accession #AAC24113, expression vector pGEX-2T), expressed in E.coli. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing POP7 are readily searchable from our website. Different antibodies against the same target such as POP7 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. POP7 also interacts with the following gene(s): HSPB1, POP4, RPP14, RPP25, RPP30, RPP38, RPP40. The following patways have been known to be associated with this gene. Nervous System Diseases, Neurodegenerative Diseases are some of the diseases may be linked to Ribonuclease P Protein Subunit p20 (RNaseP Protein p20, RPP20, 0610037N12Rik, hPOP7, Processing of Precursor 7 Ribonuclease P/MRP Subunit (S. cerevisiae), POP7, Ribonucleases P/MRP Protein Subunit POP7 Homolog, RPP2).