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anti-PRDX4 antibody product blog

Posted on 2015-09-28 08:55:21 by mybiosource_staff
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Tags: Antibody; Monoclonal Antibody; PRDX4; anti-PRDX4 antibody; Peroxiredoxin IV;
The PRDX4 prdx4 (Catalog #MBS833757) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Peroxiredoxin IV antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Peroxiredoxin IV can be used in a range of immunoassay formats including, but not limited to, Immunoprecipitation (IP).
IP 1-2ul/400ul lysates. Researchers should empirically determine the suitability of the PRDX4 prdx4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The PRDX4 prdx4 product has the following accession number(s) (GI #5453549) (NCBI Accession #NP_006397.1) (Uniprot Accession #Q13162). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Peroxiredoxin IV antibody with the following immunoassay(s):
Immunofluorescence (IF) ()
Immunofluorescence (IF) PRDX4.

Western Blot (WB) ()
Western Blot (WB) PRDX4.

Mouse monoclonal Peroxiredoxin IV antibody.

Biological Significance: Peroxiredoxin is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, particularly amino-terminal region containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1-Cys Prxsubgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20 ?30 kilodalton in molecular size and vary in subcellular localization: Prx I, II, and VI incytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol (1). Immunogen: Peroxiredoxin IV antibody was raised in Mouse using recombinant human protein purified from E Coli as the immunogen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PRDX4 are readily searchable from our website. Different antibodies against the same target such as PRDX4 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. PRDX4 also interacts with the following gene(s): ERP44, GPX4, PRDX5, TXNDC5. Blood, Bone, Bone Marrow, Brain, Liver, Lung, Muscle, Pancreas, Prostate, Vascular tissues are correlated with this protein.
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