anti-PROZ antibody product blog
Tags: Antibody; PROZ; Monoclonal Antibody; anti-PROZ antibody;
The PROZ proz (Catalog #MBS475934) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-PROZ Mouse mAb reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s PROZ can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the PROZ proz for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The PROZ proz product has the following accession number(s) (GI #823674522) (NCBI Accession #AKI72472.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-PROZ Mouse mAb with the following immunoassay(s):
Western Blot (WB) (Western blot analysis using PROZ mouse mAb against human plasma (1).)
Entrez Summary: PROZ protein Z, vitamin K-dependent plasma glycoprotein. It is 62 kDa large and 396 amino acids long. It has four domains: a gla-rich region, two EGF-like domains and a trypsin-like domain. It lacks the serine residue that would make it catalytically active as a serine protease. It is a member of the coagulation cascade, the group of blood proteins that leads to the formation of blood clots. It is vitamin K-dependent, and its functionality is therefore impaired in warfarin therapy. It is a glycoprotein. Although it is not enzymatically active, it is structurally related to several serine proteases of the coagulation cascade: factors VII, IX, X and protein C. The carboxyglutamate residues (which require vitamin K) bind protein Z to phospholipid surfaces. The main role of protein Z appears to be the degradation of factor Xa. This is done by protein Z-related protease inhibitor (ZPI), but the reaction is accelerated 1000-fold by the presence of protein Z. Oddly, ZPI also degrades factor XI, but this reaction does not require the presence of protein Z. In some studies, deficiency states have been associated with a propensity to thrombosis. Others, however, link it to bleeding tendency; there is no clear explanation for this, as it acts physiologically as an inhibitor, and deficiency would logically have led to a predisposition for thrombosis.
Immunogen: Purified recombinant fragment of PROZ expressed in E Coli. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PROZ are readily searchable from our website. Different antibodies against the same target such as PROZ may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.