anti-PSEN1 antibody product blog
Tags: Antibody; Monoclonal Antibody; PSEN1; anti-PSEN1 antibody; Presenilin 1, Loop, aa263-378;
The PSEN1 n/a (Catalog #MBS603706) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Presenilin 1, Loop, aa263-378 reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Presenilin 1, Loop, aa263-378 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunocytochemistry (ICC).Suitable for use in ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry.
Dilution: Western blot: Recognizes a protein of approximately 18-20kD, and occasionally there is a doublet (the top band of which is phosphorylated).
Immunohistochemistry: 3% paraformaldehyde fixed tissue. Works on paraffin embedded tissue sections. Researchers should empirically determine the suitability of the PSEN1 n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PSEN1 n/a product has the following accession number(s) (GI #1479974) (Uniprot Accession #Q53FV8). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Presenilin 1, Loop, aa263-378 with the following immunoassay(s):
Testing Data (MBS603706 localization of Presenilin 1in rat cerebral cortex.)
Testing Data (PC12 lysate was resolved by electrophoresis, transferred to PVDF membrane and probed with MBS603706 (1:500). Proteins were visualized using goat anti-mouse secondary antibody conjugated to HRP and a chemiluminescence detection system.)
Testing Data (Confolcal fluorescence analysis of A431 using MBS603706 (Red). Actin filaments have been labeled with Alexa Fluor 488 -Phalloidin (Green). Nuclear is stained with DAPI (Blue).)
Presenilin is a probable catalytic subunit of the gamma-secretase complex, an endoprotease.
Immunogen: Human presenilin-1, loop fusion protein (amino acids 263-378). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PSEN1 are readily searchable from our website. Different antibodies against the same target such as PSEN1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Blood, Brain, Embryonic Tissue, Kidney, Liver, Muscle, Pharynx, Skin, Spinal Cord, Vascular tissues are correlated with this protein. PSEN1 also interacts with the following gene(s): APH1A, APP, BACE1, CASP3, CTNNB1, GFAP, MAPT, NCSTN, NOTCH1, PSENEN.