anti-PTPN1� antibody product blog
Tags: Antibody; Monoclonal Antibody; PTPN1�; anti-PTPN1� antibody;
The PTPN1� ptpn1 (Catalog #MBS2543920) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti Human�PTPN1� Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s PTPN1� can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA).ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human PTPN1. The detection limit for Human PTPN1 is approximately 0.039 ng/well. Researchers should empirically determine the suitability of the PTPN1� ptpn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PTPN1� ptpn1 product has the following accession number(s) (GI #13543101). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1B contains 1 tyrosine-protein phosphatase domain and is expressed in many tissues. PTP1B is localized to the cytoplasmic face of the endoplasmic reticulum. PTP1B was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of PTP1B in cell growth control, and cell response to IFN stimulation.
Immunogen: Recombinant Human PTP1B/PTPN1 protein
Buffer: 0.2 mum filtered solution in PBS with 5% trehalose. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PTPN1� are readily searchable from our website. Different antibodies against the same target such as PTPN1� may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Cardiovascular Diseases, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 2, Disease Models, Animal, Hyperglycemia, Hyperinsulinism, Inflammation, Insulin Resistance, Necrosis, Obesity are some of the diseases may be linked to Rabbit anti Human�PTPN1� Monoclonal Antibody. The following patways have been known to be associated with this gene. PTPN1� also interacts with the following gene(s): Akt1, Bcar1, Egfr, Grb2, Insr, Irs1, Jak1, Jak2, Src, Tyk2.