|The PTPN1 n/a (Catalog #MBS604517) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Protein Tyrosine Phosphatase 1B (PTP1B, PTP-1B, Protein Tyrosine Phosphatase Non-receptor Type 1, PTPN1, Tyrosine-protein Phosphatase Non-receptor Type 1) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s Protein Tyrosine Phosphatase 1B can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 0.25ug/ml
Western Blot: 0.5-2.5ug/ml. Researchers should empirically determine the suitability of the PTPN1 n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The PTPN1 n/a product has the following accession number(s) (GI #13919645) (Uniprot Accession #Q96QT9). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.
Immunogen: Recombinant protein encoding aa1~321 of human PTP1B. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PTPN1 are readily searchable from our website. Different antibodies against the same target such as PTPN1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. PTPN1 also interacts with the following gene(s): AKT1, BCR, CTNNB1, EGFR, IGF1R, IRS1, JAK2, MAPK1, SRC, TYK2.