anti-PUMA antibody product blog
Tags: Antibody; PUMA; Monoclonal Antibody; anti-PUMA antibody;
The PUMA bbc3 (Catalog #MBS9400119) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The PUMA Monoclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s PUMA can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the PUMA bbc3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The PUMA bbc3 product has the following accession number(s) (GI #187829730) (NCBI Accession #NP_001120712.1) (Uniprot Accession #Q9BXH1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the PUMA Monoclonal Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of PUMA expression in K562 cell lysate with PUMA antibody at (A) 2.5 and (B) 5 ug/mL.)
Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMAa and PUMAb. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
Immunogen Type: Recombinant protein
Immunogen Description: Recombinant protein corresponding to amino acids 76 - 170 of human PUMA-alpha. Target Name: PUMA. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing PUMA are readily searchable from our website. Different antibodies against the same target such as PUMA may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Bone, Brain, Eye, Intestine, Kidney, Lung, Muscle, Prostate, Skin, Stomach tissues are correlated with this protein. Adenocarcinoma, Brain Diseases, Breast Neoplasms, Carcinoma, Carcinoma, Squamous Cell, Inflammation, Lung Diseases, Lung Neoplasms, Necrosis, Nervous System Diseases are some of the diseases may be linked to PUMA Monoclonal Antibody.