|The RHOB rhob (Catalog #MBS602314) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The RhoB (ARH6, ARHB, RHOH6, Ras homolog family member B, ARH6, Aplysia Ras-related homolog 6, ARHB, RhoH6) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s RhoB can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
Suitable for use in Western Blot. Researchers should empirically determine the suitability of the RHOB rhob for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The RHOB rhob product has the following accession number(s) (GI #4757764) (NCBI Accession #NP_004031.1) (Uniprot Accession #P62745). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
RhoB mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development.
Immunogen: Partial sequence of recombinant full-length protein to human RhoB. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing RHOB are readily searchable from our website. Different antibodies against the same target such as RHOB may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Bone, Brain, Heart, Kidney, Liver, Lung, Nerve, Skin, Vascular tissues are correlated with this protein. Brain Diseases, Breast Neoplasms, Cell Transformation, Neoplastic, Inflammation, Kidney Diseases, Liver Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Neoplasms, Neoplasms, Experimental are some of the diseases may be linked to RhoB (ARH6, ARHB, RHOH6, Ras homolog family member B, ARH6, Aplysia Ras-related homolog 6, ARHB, RhoH6). RHOB also interacts with the following gene(s): ARHGDIA, ARHGDIG, ARHGEF1, ARHGEF2, GRLF1, ROCK2, TIAM1, VAV1, VAV2. The following patways have been known to be associated with this gene.