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anti-RPS6KA1 antibody product blog

Posted on 2016-06-01 03:47:42 by mybiosource_staff
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Tags: Antibody; Monoclonal Antibody; anti-RPS6KA1 antibody; RPS6KA1; p90RSK;
The p90RSK rps6ka1 (Catalog #MBS475303) is an Antibody produced from Mouse
Source: Human and is intended for research purposes only. The product is available for immediate purchase. The Anti-p90RSK Mouse mAb reacts with Human, Mouse, Monkey and may cross-react with other species as described in the data sheet. MyBioSource\'s p90RSK can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP).
WB: 1:1000. Researchers should empirically determine the suitability of the p90RSK rps6ka1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The p90RSK rps6ka1 product has the following accession number(s) (GI #55743134) (NCBI Accession #NP_001006666.1) (Uniprot Accession #Q15418). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-p90RSK Mouse mAb with the following immunoassay(s):
Western Blot (WB) (Western blot detection of p90RSK in COS7, 3T3, Jurkat, Hela and A549 cell lysates using p90RSK mouse mAb (dilution 1:1000).Predicted band size:90KDa.Observed band size:90KDa.)
Western Blot (WB) p90RSK.

Immunoprecipitation (IP) (Immunoprecipitation analysis of Hela cell lysates using p90RSK mouse mAb.)
Immunoprecipitation (IP) p90RSK.

Entrez Summary: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
UniPort Summary Function: Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.

Immunogen: Purified recombinant human p90RSK protein fragments expressed in E Coli.
Sensitivity: This antibody detects endogenous levels of p90RSK and does not cross-react with related proteins.
Sequence Similarities: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 2 protein kinase domains. Subunit Structure: Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates following mitogenic stimulation. Interacts with ETV1/ER81 and FGFR1. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing p90RSK are readily searchable from our website. Different antibodies against the same target such as p90RSK may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.
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