|The SEMA4A sema4a (Catalog #MBS692370) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti-Human Semaphorin 4A reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Semaphorin 4A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the SEMA4A sema4a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The SEMA4A sema4a product has the following accession number(s) (GI #300863072) (NCBI Accession #NP_001180229.1) (Uniprot Accession #Q9H3S1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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The Semaphorins make up the largest family of axon guidance cues yet described. Semaphorins are divided into 8 classes (classes 3-7 found in vertebrates). Class 3 Semaphorins are secreted, classes 4 through 6 are transmembrane proteins, and class 7 are membrane associated via glycosylphosphatidylinositol (GPI) linkage. They are characterized structurally by a conserved ~400 amino acid sema domain. They are classically described as collapsing factors and mediators of axon repulsion, although they may also act as context-dependent chemoattractants. Semaphorins have been shown to have roles in cardiovascular development and in the regulation of immune cell antigen presentation. Receptors or receptor complexes that mediate semaphorin signaling include proteins of the Neuropilin and Plexin families.
Reconstitution: Reconstitute the antibody with 500 ul sterile PBS and the final concentration is 200 ug/ml. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing SEMA4A are readily searchable from our website. Different antibodies against the same target such as SEMA4A may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Blood, Brain, Embryonic Tissue, Eye, Liver, Lung, Lymph, Lymph Node, Pancreas, Skin tissues are correlated with this protein. Cardiovascular Diseases, Disease Models, Animal, Fatty Liver, Fibrosis, Heart Diseases, Hyperplasia, Inflammation, Necrosis, Pneumonia are some of the diseases may be linked to Mouse Anti-Human Semaphorin 4A. SEMA4A also interacts with the following gene(s): CD72, PLXNB1, PLXND1, PRPF3, PRPF31.