anti-SerpinA3� antibody product blog
Tags: Antibody; Monoclonal Antibody; SerpinA3�; anti-SerpinA3� antibody;
The SerpinA3� serpina3 (Catalog #MBS2543923) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti Human�SerpinA3� Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s SerpinA3� can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA).ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human SERPINA3. The detection limit for Human SERPINA3 is approximately 0.0195 ng/well. Researchers should empirically determine the suitability of the SerpinA3� serpina3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The SerpinA3� serpina3 product has the following accession number(s) (GI #47124538). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Human SerpinA3, also known as Alpha 1-antichymotrypsin (AACT), is a plasma alpha globulin glycoprotein, and is a member of serpin superfamily of the serine protease inhibitors consisting of at least 35 members. SerpinA3 has been demonstrated to inhibit the activity of certain serine proteases, such as cathepsin G found in neutrophils, and chymases present in mast cells, by inducing a major conformational rearrangement, and thus protects some tissues from damage caused by proteolytic enzymes. This enzyme is produced primarily in the liver, and is identified as an acute-phase inflammatory protein. SerpinA3 deficiency has been associated with liver disease, and mutations of this gene have been observed in patients with Parkinson disease and chronic obstructive pulmonary disease. In addition, ACT gene polymorphism has been implicated with Alzheimer\'s disease (AD), cerebral amyloid angiopathy (CAA), as well as stroke, since SerpinA3 is a major constituent of the plaques in AD and an inhibitor of amyloid beta peptide degradation.
Immunogen: Recombinant Human SerpinA3 Protein
Buffer: This antibody was obtained from a rabbit immunized with purified, recombinant Human SerpinA3 (rh SerpinA3; NP_001076.2; Met 1-Ala 423). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing SerpinA3� are readily searchable from our website. Different antibodies against the same target such as SerpinA3� may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. SerpinA3� also interacts with the following gene(s): CTSG, IL6.