|The Slc17a7 slc17a7 (Catalog #MBS802712) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The VGLUT1 Antibody: ATTO 700 reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s VGLUT1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB).
1:1000 (WB). Researchers should empirically determine the suitability of the Slc17a7 slc17a7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Slc17a7 slc17a7 product has the following accession number(s) (GI #16758726) (NCBI Accession #NP_446311.1) (Uniprot Accession #Q62634). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the VGLUT1 Antibody: ATTO 700 with the following immunoassay(s):
Testing Data (Western blot analysis of VGlut1 on rat brain membrane tissues using a 1:1000 dilution.)
Background Info: Detects ~52kDa. No cross-reactivity against VGLUT2.
Scientific Background: VGLUT1 is expressed in a subset of glutamate neurons and transports glutamate into native synaptic vesicles from the brain, exhibiting a conductance for chloride that is blocked by glutamate (1). Vesicular glutamate transport has a substantially lower apparent affinity than the plasma membrane excitatory amino acid transporters. Glutamate transport by VGLUT1 is saturated with a K(m) of approximately 2 mM, in the same range as transport by synaptic vesicles. Finally, plasma membrane glutamate transporters recognize both aspartate and glutamate as substrates, whereas VGLUT1 does not recognize aspartate (2).
Conjugate: ATTO 700. Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Slc17a7 are readily searchable from our website. Different antibodies against the same target such as Slc17a7 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Brain, Dorsal Root Ganglion, Eye, Heart, Inner Ear, Nerve, Pineal Gland tissues are correlated with this protein. Cognition Disorders, Epilepsy, Learning Disorders, Memory Disorders, Mental Disorders, Nerve Degeneration, Nervous System Diseases, Neurobehavioral Manifestations, Pain, Seizures are some of the diseases may be linked to VGLUT1 Antibody: ATTO 700. The following patways have been known to be associated with this gene.