anti-SLPI antibody product blog
Tags: Antibody; Monoclonal Antibody; SLPI; anti-SLPI antibody; Secretory Leukocyte Protease Inhibitor;
The SLPI slpi (Catalog #MBS601321) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Secretory Leukocyte Protease Inhibitor (SLPI) (Biotin) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Secretory Leukocyte Protease Inhibitor can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC).Can be used for Immunohistology on frozen and paraffin sections. Furthermore the antibody is useful for Western Blot and immunoassays.
Dilution: Immunohistology: 1:10
Western Blot: 1:10. Researchers should empirically determine the suitability of the SLPI slpi for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The SLPI slpi product has the following accession number(s) (GI #758101) (Uniprot Accession #P03973). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
SLPI is a 11.7kD cationic inhibitor of neutrophil elastase and to a lesser extent of cathepsin G. It is locally produced by epithelial cells in the lung, skin and other organs and by Polymorphonuclear leukocytes (PMN) and (in mice) by macrophages. In addition to its proteinase inhibitory properties that may serve to protect against proteolytic injury, it was recently shown that SLPI also displays several other functions such as antimicrobial and anti-inflammatory activities. These appear to be independent of its ability to inhibit PMN serine proteinases. SLPI has also been demonstrated to display antibacterial and antifungal activity at concentrations in which SLPI is present in mucosal secretions including those of the lung. Another possible role for SLPI is inhibition of protein-disulfide isomerase that is considered essential for invasion of a cell by the Human Immunodeficiency Virus (HIV).
In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing SLPI are readily searchable from our website. Different antibodies against the same target such as SLPI may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. SLPI also interacts with the following gene(s): CTSL1, GRN, PLSCR1. Blood, Cervix, Heart, Intestine, Liver, Lung, Mouth, Skin, Trachea, Uterus tissues are correlated with this protein. Asthma, Bacterial Infections, Carcinoma, Fibrosis, Genital Neoplasms, Female, Immune System Diseases, Inflammation, Neoplasms, Ovarian Neoplasms, Urogenital Neoplasms are some of the diseases may be linked to Secretory Leukocyte Protease Inhibitor (SLPI) (Biotin).