anti-SNAI1 antibody product blog
Tags: Antibody; anti-SNAI1 antibody; SNAI1; Monoclonal Antibody;
The SNAI1 snai1 (Catalog #MBS6010686) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The SNAI1 reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s SNAI1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).Western Bloting: 1:500-1:2000., ELISA: Suggested dilution 1:10000., Optimal dilutions to be determined by the researcher. Researchers should empirically determine the suitability of the SNAI1 snai1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The SNAI1 snai1 product has the following accession number(s) (GI #5729674) (NCBI Accession #CAB52414.1) (Uniprot Accession #O95863). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells. Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines. In addition, Snail blocks the cell cycle and confers resistance to cell death. Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function.Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney.
Immunogen: Purified recombinant fragment of human SNAI1 expressed in E. coli. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing SNAI1 are readily searchable from our website. Different antibodies against the same target such as SNAI1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Blood, Bone, Brain, Embryonic Tissue, Intestine, Kidney, Lung, Pancreas, Skin, Vascular tissues are correlated with this protein. Breast Neoplasms, Carcinoma, Squamous Cell, Congenital Abnormalities, Disease Models, Animal, Liver Diseases, Lung Diseases, Lung Neoplasms, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasms are some of the diseases may be linked to SNAI1. SNAI1 also interacts with the following gene(s): BTRC, EGR1, HDAC1, MYC, SMAD4.