|The SRGN srgn (Catalog #MBS6000626) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The SRGN (Serglycin, Hematopoietic Proteoglycan Core Protein, Platelet Proteoglycan Core Protein, P.PG, Secretory Granule Proteoglycan Core Protein, PRG, PRG1, FLJ12930, MGC9289) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s SRGN can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).
Suitable for use in ELISA and Western Blot. Researchers should empirically determine the suitability of the SRGN srgn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The SRGN srgn product has the following accession number(s) (GI #45935371) (NCBI Accession #NP_002718.2) (Uniprot Accession #P10124). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
MMQKLLKCSR LVLALALILV LESSVQGYPT QRARYQWVRC NPDSNSANCL EEKGPMFELL PGESNKIPRL RTDLFPKTRI QDLNRIFPLS EDYSGSGFGS GSGSGSGSGS GFLTEMEQDY QLVDESDAFH DNLRSLDRNL PSDSQDLGQH GLEEDFML.
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This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq].
Immunogen: Full length recombinant corresponding to aa1-159 from human SRGN (AAH15516) with GST tag. MW of the GST tag alone is 26kD. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing SRGN are readily searchable from our website. Different antibodies against the same target such as SRGN may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. SRGN also interacts with the following gene(s): CLU. The following patways have been known to be associated with this gene. Blood, Bone, Kidney, Liver, Muscle, Nerve, Uterus, Vascular tissues are correlated with this protein. Adenocarcinoma, Carcinoma, Carcinoma, Hepatocellular, Inflammation, Kidney Diseases, Liver Diseases, Liver Neoplasms, Neoplasms, Neoplasms, Experimental, Pain are some of the diseases may be linked to SRGN (Serglycin, Hematopoietic Proteoglycan Core Protein, Platelet Proteoglycan Core Protein, P.PG, Secretory Granule Proteoglycan Core Protein, PRG, PRG1, FLJ12930, MGC9289).