|The syntaxin n/a (Catalog #MBS520459) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-human syntaxin, FITC, (clone SP6), (Mouse IgG1) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s syntaxin can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC).
This antibody is suitable for use in Western Blot, ELISA, Flow Cytometry and Immunofluorescence (1:500 dilution). Researchers should empirically determine the suitability of the syntaxin n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
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Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-human syntaxin, FITC, (clone SP6), (Mouse IgG1) with the following immunoassay(s):
Syntaxin 1 is a 35 KDa integral membrane protein that possesses a single C-terminal transmembrane domain, a SNARE domain (H3) and an N-terminal regulatory domain (Habc). Two isoforms of Syntaxin 1 have been identified, Syntaxin 1A and Syntaxin1B. Syntaxin 1A localizes to nerve terminals of sensory neurons and nerve fibres reaching small blood vessels. Whereas Syntaxin 1B is localized to motor end plates and muscle spindles. Syntaxin 1A resides at the pre-synaptic membrane and is a key component of the SNARE core complex that also includes Synaptobrevin-2 and SNAP25. Several other proteins including synaptotagmin-1, Munc18-1 and complexin also bind this complex to form the functional SNARE complex. SNARE is responsible for driving secretory vesicle docking, fusion and ultimately exocytosis.
Immunocyte Donor: Mouse monoclonal antibodies raised against synaptic vesicle-containing fractions immunoprecipitated from human brain homogenates using anti-human synaptophysin monoclonal Abs. Presentation: Biotin/FITC conjugated IgG buffered in PBS, 0.02% NaN3 and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing syntaxin are readily searchable from our website. Different antibodies against the same target such as syntaxin may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.