|The tau tau (Catalog #MBS831388) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Tau antibody reacts with Mouse, Rat. Does not react with the most carboxyl-terminal peptide (396 - 441) of normal Human Tau protein. and may cross-react with other species as described in the data sheet. MyBioSource\'s Tau can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB).
IHC: 5 ug/ml
WB: 5 ug/ml. Researchers should empirically determine the suitability of the tau tau for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The tau tau product has the following accession number(s) (GI #21357661) (NCBI Accession #NP_651575.1) (Uniprot Accession #Q9VB13). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Mouse monoclonal Human Tau antibody (phosphorylated tau specific).
Source Note: Supernatant
Biological Significance: Six tau isoforms exist in human brain tissue, and they are distinguished by their number of binding domains. Three isoforms have three binding domains and the other three have four binding domains. The binding domains are located in the carboxy-terminus of the protein and are positively-charged (allowing it to bind to the negatively-charged microtubule). The isoforms with four binding domains are better at stabilizing microtubules than those with three binding domains. The isoforms are a result of alternative splicing in exons 2, 3, and 10 of the tau gene. Immunogen: Tau (phosphorylated) antibody was raised in mouse using PHF (paired helical filament) obtained from AD brain as the immunogen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing tau are readily searchable from our website. Different antibodies against the same target such as tau may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Head, Testis, Uncharacterized Tissue, Whole Body tissues are correlated with this protein. tau also interacts with the following gene(s): Appl, CHIP, Mbs, Nmnat, par-1, sgg.