anti-TC-PTP antibody product blog
Tags: Antibody; Monoclonal Antibody; TC-PTP; anti-TC-PTP antibody;
The TC-PTP n/a (Catalog #MBS588302) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s TC-PTP can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the TC-PTP n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the TC-PTP (N term) Mouse Monoclonal Antibody (3E2) - Purified with the following immunoassay(s):
Testing Data
Testing Data
Protein tyrosine phosphatases (PTP) belong to a large family of enzymes involved in the regulation of cellular signaling and homeostasis. They all possess a 240 amino acid PTP domain. The T-cell protein tyrosine phosphatase (TC-PTP) is predominantly expressed in the hematopoietic lineage. TC-PTP null mice suffer severe defects in the hematopoietic compartment and die at 3-5 weeks of age from severe anemia. TC-PTP -/- murine embryonic fibroblasts have a slow progression through the G1 phase of the cell cycle and have compromised NF- B activation. JAK 1 and 3 have been identified as physiological substrates of TC-PTP. Recent genetic studies have revealed an association between the PTPN2 (TC-PTP) gene and diseases like type 1 diabetes and Crohn�s disease.
Conjugation: None. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing TC-PTP are readily searchable from our website. Different antibodies against the same target such as TC-PTP may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.