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anti-TDP43 antibody product blog

Posted on 2016-01-10 09:15:16 by mybiosource_staff
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Tags: Antibody; TDP43; Monoclonal Antibody; anti-TDP43 antibody;
The TDP43 n/a (Catalog #MBS415162) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s TDP43 can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF), Western Blot (WB).
1:500 and higher for immunofluorescence, 1:2500 and lower for western blotting. Researchers should empirically determine the suitability of the TDP43 n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the TDP43 Antibody with the following immunoassay(s):
Western Blot (WB)
Western Blot (WB) TDP43.

Testing Data #2
Testing Data #2 TDP43.

TDP43 is a The TARDBP gene encodes the 43-kD TAR DNA-binding protein, which was originally identified as a transcriptional repressor that binds to TAR DNA of human immunodeficiency virus type 1. It is also involved in regulation of gene expression and splicing (summary by Benajiba et al., 2009).

Immunogen: TDP43 was originally identified as a protein which binds to the "transactivation response" (TAR) sequence found in the long terminal repeat of the HIV-1 virus genome (1). UV cross-linking of HeLa cell extract revealed a 43kDa protein which was cloned and sequenced and shown to contain a two copies of the ~90 amino acid RRM domain. RRM is an acronym for RNA Recognition Motif, and this domain is found in many proteins which bind single stranded RNA and some which bind single stranded DNA. It also has a single Zinc Finger domain of the ZnF_RBZ subtype found in Ran binding proteins. Ran is a small G protein related to p21-Ras which regulates the import and export of proteins to the nucleus. The protein is frequently refered to by the acronym TDP43 corresponds to "TAR DNA binding protein of molecular weight 43kDa", although the Human Genome Organization (HUGO) Gene Nomenclature Committee (HGNC) name is TARDBP. Northern blots showed that the protein is ubiquitous in tissue expression. Much interest has been focused on TDP43 recently due to its association with the inclusions seen in frontotemporal lobar degeneration and Amyotrophic Lateral Sclerosis (2). The protein is present in these inclusions in a partially degraded, hyperphosphorylated and ubiquitinated form. For a recent review of the role in TDP43 in various neurological disorders see reference 3. This antibody has been used in a recent peer reviewed publication, showing that it works well on western blots and on histological sections (4). The HGNC name for this protein is TARDBP. Storage Buffer: PBS, pH 7.4 with 0.02% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing TDP43 are readily searchable from our website. Different antibodies against the same target such as TDP43 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.
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