|The CD248 cd248 (Catalog #MBS2542325) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CD248 Monoclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s CD248 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA).
IHC: 1:50-1:500. Researchers should empirically determine the suitability of the CD248 cd248 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The CD248 cd248 product has the following accession number(s) (GI #9966885) (NCBI Accession #NP_065137.1) (Uniprot Accession #Q9HCU0). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the CD248 Monoclonal Antibody with the following immunoassay(s):
Western Blot (WB) (Western Blot analysis of HUVEC cells using TEM1 Monoclonal Antibody at dilution of 1:2000)
TEM1 (Tumor endothelial marker 1), also named as CD248, Endosialin and CD164L1, is a C-type lectin-like domain (CTLD) containing type I transmembrane glycoprotein. It is now considered to be a highly selective marker for activated perivascular and stromal cells, detected in most cancers and at least some inflammatory disorders. CD248 plays a role in tumor angiogenesis. It is a potential diagnostic tool and therapeutic target of inflammatory and malignant disease. Two isoforms of human TEM1 exist. The calculated molecular weights of the two isoforms are 81 kDa and 46 kDa, respectively. Native TEM1 can be glycosylated, and the glycosylated form has a larger apparent molecular weight than 81 kDa.
Immunogen: Fusion protein of TEM1. Buffer: PBS with 0.1% sodium azide, 50% glycerol, PH7.3
Conjugation: Unconjugated. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing CD248 are readily searchable from our website. Different antibodies against the same target such as CD248 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. CD248 also interacts with the following gene(s): ANTXR1, PDGFRB, SP1. Bone, Bone Marrow, Brain, Embryonic Tissue, Eye, Kidney, Lung, Lymph Node, Muscle, Vascular tissues are correlated with this protein. Disease Models, Animal, Fibrosis, Immune System Diseases, Inflammation, Intestinal Neoplasms, Kidney Diseases, Lung Diseases, Necrosis, Neoplasms, Experimental, Ovarian Diseases are some of the diseases may be linked to CD248 Monoclonal Antibody.