|The THAP1 thap1 (Catalog #MBS6002395) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The THAP1 (THAP Domain-containing Protein 1, 4833431A01Rik, DYT6, FLJ10477, MGC33014) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s THAP1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunofluorescence (IF).
Suitable for use in Immunofluorescence, ELISA and Western Blot.
Dilution: Immunofluorescence: 10ug/ml. Researchers should empirically determine the suitability of the THAP1 thap1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The THAP1 thap1 product has the following accession number(s) (GI #40068500) (NCBI Accession #NP_945354.1) (Uniprot Accession #Q9NVV9). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
MVQSCSAYGC KNRYDKDKPV SFHKFPLTRP SLCKEWEAAV RRKNFKPTKY SSICSEHFTP DCFKRECNNK LLKENAVPTI FLCTEPHDKK EDLLEPQEQL PPPPLPPPVS QVDAAIGLLM PPLQTPVNLS VFCDHNYTVE DTMHQRKRIH QLEQQVEKLR KKLKTAQQRC RRQERQLEKL KEVVHFQKEK DDVSERGYVI LPNDYFEIVE VPA.
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DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5\'-[AT]NTNN[GT]GGCA[AGT]-3\' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
Immunogen: Full length recombinant corresponding to aa1-214 from human THAP1 (AAH21721) with GST tag. MW of the GST tag alone is 26kD. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing THAP1 are readily searchable from our website. Different antibodies against the same target such as THAP1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Disease Models, Animal, Dystonia, Dystonia 6, torsion, Dystonic Disorders, Learning Disorders, Neoplasms are some of the diseases may be linked to THAP1 (THAP Domain-containing Protein 1, 4833431A01Rik, DYT6, FLJ10477, MGC33014). THAP1 also interacts with the following gene(s): HCFC1, OGT, RRM1, TOR1A. Blood, Brain, Muscle, Prostate, Vascular tissues are correlated with this protein.